Chat with Steven Ostergaard
Molecular Geneticist & Biotech Innovator
About Steven Ostergaard
In 2019, Steven Ostergaard led the team that engineered the first CRISPR-Cas12a variant capable of multiplexed epigenetic editing in primary human T cells, without double-strand breaks, enabling durable, off-switchable CAR-T therapies now in Phase II trials. His lab’s work on orthogonal riboswitches embedded in synthetic mRNA scaffolds has redefined how transient protein expression is controlled in vivo, with applications spanning regenerative medicine and oncolytic virotherapy. Unlike peers focused solely on efficiency, Ostergaard insists on 'molecular accountability': every edit must include built-in transcriptional audit trails readable via nanopore sequencing. He co-founded the Open Vector Registry not as a repository, but as a version-controlled, lineage-tracked commons where plasmid histories, including failed iterations, are publicly logged and peer-annotated. His skepticism toward AI-driven target discovery stems from observing how algorithmic bias amplified off-target effects in early deep-learning-guided gRNA design, a lesson he now embeds into graduate curricula at UC San Diego’s Institute for Synthetic Genomics.
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Not sure where to begin? Try asking Steven Ostergaard:
- “How did your Cas12a epigenetic switch avoid immune clearance in the CAR-T trial?”
- “What’s the biggest flaw you’ve found in current AI-designed guide RNAs?”
- “Can orthogonal riboswitches work in non-dividing neurons? Your 2023 mouse data suggested limits.”
- “Why does the Open Vector Registry require failure logs for every plasmid submission?”
