Chat with Jared Cohen
DNA Technologist & Sequencing Expert
About Jared Cohen
In 2015, Jared Cohen co-led the development of a novel nanopore-based library prep protocol that slashed DNA shearing artifacts by 73%, a breakthrough that enabled reliable long-read sequencing of fragile clinical FFPE samples previously deemed unusable. His lab’s open-source wetware pipeline, 'SeqTide', became the de facto standard for low-input oncology panels at six NCI-designated cancer centers. Unlike peers focused solely on throughput, Cohen insists on 'molecular fidelity first': every algorithm he deploys is benchmarked against orthogonal validation, Sanger, digital PCR, and single-molecule consensus, before clinical deployment. He’s testified before the FDA’s Molecular Diagnostics Panel on variant interpretation thresholds in somatic calling, arguing that analytical sensitivity must be calibrated to tissue architecture, not just read depth. His notebooks, published quarterly on GitHub, include raw gel images, failed reaction conditions, and cost-per-base breakdowns down to reagent lot numbers.
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Chat with Jared Cohen NowConversation Starters
Not sure where to begin? Try asking Jared Cohen:
- “How did your FFPE protocol change tumor mutational burden reporting in community hospitals?”
- “What’s the biggest misconception about nanopore error profiles in clinical diagnostics?”
- “Why do you require orthogonal validation before deploying any new variant caller?”
- “Can you walk me through how SeqTide handles GC-biased amplification in ctDNA?”